Reduced complement activation with heparin-coated oxygenator and tubings in coronary bypass operations
نویسندگان
چکیده
منابع مشابه
Complement Activation Induced by Different Tubings Used for Cardiopulmonary Bypass
____________ _ Complement activation induced by latex, polyvinylchloride, and silicone tubings for extracorporeal circulation was studied in 2 in vitro situations: Fresh whole human blood mixed with priming solution was circulated through 1 00 em tubing lengths for 1 hour, and small tubing pieces were incubated in fresh human serum for 7 hours. Activation of C3 and of the terminal pathway (C5-C...
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Complete heparin-coated extracorporeal circuits, including cardiotomy reservoir, have recently become available for routine cardiac surgery. The effects on complement and granulocyte activation using a heparin-coated circuit in combination with reduced systemic heparinization (activated clotting time (ACT) > 250 s) were studied in 33 patients undergoing elective first time myocardial revascular...
متن کاملComplement activation during cardiopulmonary bypass by heparin-protamine interaction.
Circulating concentrations of split products of the third complement factor (C3c and C3d) were measured in five patients before, during and after cardiopulmonary bypass. In all patients, C3d concentrations increased significantly in samples obtained after the administration of protamine sulphate. Similarly, circulating C3c was seen only in those samples obtained immediately after protamine admi...
متن کاملQuantitative evaluation of heparin-coated versus non-heparin-coated bypass circuits during cardiopulmonary bypass.
The extracorporealization of blood activates various elements of the fibrinolytic, coagulation, and complement systems. It is theorized that advancements in biocompatibility ameliorate many of the changes leading to improved patient management. The purpose of this study was to determine if heparin-coated circuit (HCC) utilization during cardiopulmonary bypass enhances patient outcomes in a cost...
متن کاملCoronary artery bypass surgery with heparin-coated perfusion circuits and low-dose heparinization.
OBJECTIVE To evaluate the safety and efficacy of heparin-coated perfusion circuits with low-dose heparinization and centrifugal pumping compared with the standard method during coronary artery bypass grafting. DESIGN Prospective, randomized, single-blind clinical trial. SETTING A primary care institution. PATIENTS Ninety patients who underwent first-time elective coronary artery bypass gr...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 1992
ISSN: 0022-5223
DOI: 10.1016/s0022-5223(19)34966-9